Dissection of affinity captured LINE - 1 macromolecular 1 complexes
نویسندگان
چکیده
Massachusetts General Hospital, Department of Pathology (Boston, MA, United States); Moscow 6 Institute of Physics and Technology, (Dolgoprudny, Russian Federation); The Rockefeller 7 University, Laboratory of Mass Spectrometry and Gaseous Ion Chemistry (New York, NY, United 8 States); Institute for Systems Genetics, NYU Langone Health, Department of Biochemistry and 9 Molecular Pharmacology (New York, NY, United States); The Rockefeller University, Laboratory 10 of Cellular and Structural Biology (New York, NY, United States); Johns Hopkins University 11 School of Medicine, McKusick-Nathans Institute of Genetic Medicine (Baltimore, MD, United 12 States); NYU Langone Health, Department of Pathology (New York, NY, United States); Johns 13
منابع مشابه
Dissection of affinity captured LINE-1 macromolecular complexes
Long Interspersed Nuclear Element-1 (LINE-1, L1) is a mobile genetic element active in human genomes. L1-encoded ORF1 and ORF2 proteins bind L1 RNAs, forming ribonucleoproteins (RNPs). These RNPs interact with diverse host proteins, some repressive and others required for the L1 lifecycle. Using differential affinity purifications, quantitative mass spectrometry, and next generation RNA sequenc...
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